Gattaca lab

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				English

田大成教授

办公地址：生科大楼B419

电话：+86-025-89686406

传真：+86-025-83592705

E-mail: dtian(at)nju.edu.cn

研究方向

从事分子和基因组的进化、植物功能基因组和生物信息学的研究

1）植物抗病基因的结构、功能、起源、变异及保存

2）DNA insertion/deletion对遗传变异的影响

3）基因组的非对称性及其非对称DNA的遗传效应

4）肿瘤基因组体细胞突变的分子遗传机制

个人简历

南京农业大学，获博士学位

澳大利亚Newcastle大学，获博士学位

澳洲 ForBio Research Pty. Ltd.研究员

芝加哥大学生态与进化学系Research Associate（1998－2003）

代表论文

Yang S, Wang L, Huang J, Zhang X, Yuan Y, Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates higher mutation rates in heterozygotes. Nature 523: 463–467

Tian D*, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes. Nature 455:105-108

Tian D, Shaw B, Chen J, Kreitman M, Bergelson J (2003) Fitness cost of R-gene mediated resistance in Arabidopsis thaliana. Nature 424:74-77

Bergelson J, Kreitman M, Stahl E, Tian D (2001) Evolutionary dynamics of plant R-genes. Science 292:2281-2285

Yang S, Li J, Zhang XH, Zhang QJ, Huang J, Chen JQ, Hartl DL, Tian D*. (2013) Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease. Proc Natl Acad Sci 110: 18572-18577

Yang S, Yuan Y, Wang L, Li J, Wang W, Liu H, Chen JQ, Hurst LD, Tian D*. (2012) Great majority of recombination events in Arabidopsis are gene conversion events. Proc Natl Acad Sci 109 :20992-20997

Araki H, Tian D, Goss EM, Jakob K, Halldorsdottir SS, Kreitman M and Bergelson J. (2006) Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis. Proc Natl Acad Sci 103:5587-5892

Tian D, Akashi H, Stahl E, Bergelson J, Kreitman M (2002) Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci 99:11525-1153

Zhang X#, Yang S#, Wang J#, Jia Y#, Huang J#, Zhong Y, Tan S, Wang L, Gu L, Chen JQ, Pan QH*, Bergelson J*, Tian D* (2015). A genome-wide survey reveals abundant rice blast R-genes in resistant cultivars. Plant J 84 :20-28 (IF5y =6.963)

Yue J-X, Meyers BC, Chen J-Q, Tian D*, Yang S. (2012) Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes. New Phytologist 193: 1049–1063 (IF=6.736)

Zhu L, Wang Q, Tang P, Araki H, Tian D*. (2009) Genome-wide association between insertions/deletions and the nucleotide diversity in bacteria. Mol Biol Evol 26:2353-2361 (IF=10.353)

Chen JQ, Wu Y, Yang H, Bergelson J, Kreitman M, Tian D*. (2009) Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria. Mol Biol Evol 26:1523-31 (IF=10.353)

Sun X, Zhang Y, Yang S, Chen JQ, Hohn B, Tian D* (2008) Insertion DNA promotes ectopic recombination during meiosis in Arabidopsis. Mol Biol Evol 25:2079-2083 (IF=10.353)

Gu T, Tan S, Gou X, Araki H, Tian D*. (2010) Avoidance of long mononucleotide repeats in codon pair usage. Genetics 186:1077-1084

Shen J, Araki H, Chen L, Chen JQ, Tian D* (2006) Unique evolutionary mechanism in R-genes under the presence/absence polymorphism in Arabidopsis thaliana. Genetics 172 (2):1243-50

其他发表论文

Li J, Zhou J, Wu, Y, Yang S, Tian D*. (2015) GC-content of synonymous codons profoundly infulences amino acid usage. G3 : Genes|Genomes|Genetics 5(10):2027-36

Tan S, Zhong Y, Hou H, Yang S, Tian D. (2012) Variation of presence/absence genes among Arabidopsis populations. BMC Evol Biol 12:86

Wang L, Si W, Yao Y, Tian D, Araki H. Yang S. (2012) Genome-wide survey of pseudogenes in 80 fully re-sequenced Arabidopsis thaliana accessions. Plos One 7(12): e51769

Tan S, Wang D, Ding J, Tian D, Zhang XH, Yang S. (2011) Adaptive evolution of Xa21 homologs in gramineae. Genteica 139:1465-1475

Wang J, Zhang L, Li J, Lawton-Rauh A, Tian D. (2011) Unusual signatures of highly adaptable R-loci in closely-related Arabidopsis species. Gene 482:24–33

Wang J, Tan SJ, Zhang L, Li P, Tian D. (2011) Co-Variation Among Major Classes of LRR-Encoding Genes in Two Pairs of Plant Species. J Mol Evol 72:498–509

Wu Y, Yuan HZ, Tan SJ, Chen JQ, Tian D, Yang HW (2011) Increased complexity of gene structure and base composition in vertebrates. Journal of Genetics and Genomics 38: 297-305

Zhang X, Wang L, Yuan Y, Tian D, Yang S. (2011) Rapid copy number expansion and recent recruitment of domains in S-receptor kinase-like genes contribute to the origin of self-incompatibility. FEBS J 278: 4323-4337

Zhang X, Feng Y, Chen H, Tian D, Yang S, Chen J-Q (2011) Relative evolutionary rates of NBS-encoding genes revealed by soybean segmental duplication. Mol Genet Genomics 285: 79-90

Yang H, Zhong Y, Peng C, Chen JQ, Tian D. (2010) Important role of indels in somatic mutations of human cancer genes. BMC Med Genet 11:128

Yue J-X, Li J, Wang D, Araki H, Tian D, Yang S (2010) Genome-wide investigation reveals high evolutionary rates in annual plants. BMC Plant Biol 10: 242

Li J, Ding J, Zhang W, Zhang Y, Tang P, Chen JQ, Tian D, Yang S. (2010) Unique pattern of number evolution in gramineous NBS-LRR genes. Mol Genet Genomics 283:427–438

Chen Q, Han Z, Jiang H, Tian D, Yang S. (2010) Strong positive selection drives rapid diversification of R-genes in Arabidopsis relatives. J Mol Evol 70: 137-148

Tang P, Zhang Y, Sun X, Tian D, Yang S, Ding J. (2010) Disease resistance signature of the leucine-rich repeat receptor-like kinase genes in four plant species. Plant Sci 179: 399-406

Zhang Y, Wang J, Zhang X, Chen JQ, Tian D, Yang S. (2009) Genetic signature of rice domestication shown by a variety of genes. J Mol Evol 68:393-402

Zhu L, Zhang Y, Zhang W, Yang S, Chen JQ, Tian D. (2009) Patterns of exon-intron architecture variation of genes in eukaryotic genomes. BMC Genomics 10:47

Yang H, Wu Y, Feng J, Yang S, Tian D (2009) Evolutionary pattern of protein architecture in mammal and fruit fly genomes. Genomics 93:90-97

Yang S, Gu T, Pan C, Feng Z, Ding J, Hang Y, Chen JQ, Tian D (2008) Genetic variation of NBS-LRR class resistance genes in rice lines. Theor Appl Genet 116:165-177

Zhang W, Sun X, Yuan H, Araki H, Wang J, Tian D (2008) The pattern of insertion/deletion polymorphism in Arabidopsis thaliana. Mol Genet Genomics 280:351-361

Yang S, Zhang X, Yue JX, Tian D, Chen JQ. (2008) Recent duplication dominates the expansion of the NBS-encoding genes in two woody species Mol Genet Genomics 280: 187-198

Du J, Gu T, Tian H, Araki H, Yang YH, Tian D (2008) Grouped nucleotide polymorphism: A major contributor to genetic variation in Arabidopsis. Gene 426:1-6

Ding J, Zhang W, Jing Z, Chen JQ, Tian D (2007) Unique pattern of R-gene variation within populations in Arabidopsis. Mol Genet Genomics 277:619-629

Yang S, Jiang K, Araki H, Ding J, Yang Y, Tian D (2007) A molecular isolation mechanism associated with high intra-specific diversity in rice. Gene 394:87-95

Ding J., Cheng H., Jin Q., Araki H., Yang Y, Tian D (2007) Contrasting patterns of evolution between allelic groups at a single locus in Arabidopsis. Genetica 29:235-242

Ding J, Araki H, Wang Q, Zhang P, Chen JQ, Tian D (2007) Highly asymmetric rice genomes. BMC Genomics 8:154

Jiang H, Wang C, Ping L, Tian D, Yang S. (2007) Pattern of LRR nucleotide variation in plant resistance genes. Plant Science 173:253-261

Yang S, Feng Z, Zhang X, Jiang K, Jin X, Hang Y, Chen JQ, Tian D (2006) Genome-wide investigation on the genetic variations of rice disease resistance genes. Plant Mol Biol 62:181-193

Zhou T, Wang Y, Chen JQ, Araki H, Jing Z, Jiang K, Shen J, Tian D (2004). Genome-wide identification of NBS genes in rice reveals significant expansion of divergent non-TIR NBS Genes. Mol Genet Genomics 271:402-415

Mauricio R, Stahl E, Korves T, Tian D, Kreitman M & Bergelson J (2003) Natural selection for polymorphism in the disease resistance gene RPS2 of Arabidopsis. Genetics 163(2):735-746

Tian D, Niu C & Rose R. (2002) DNA transfer by highly asymmetric somatic hybridisation in Medicago truncatula x Medicago rugosa and Medicago truncatula x Medicago scutellata. Theo Appl Genet 104:9-16

Tian D, & Rose R (1999) Plant regeneration of asymmetric somatic hybrids between annual Medicago truncatula and Medicago scutellata. Plant Cell Report 18:989-996

Tian D (1994) 杂交水稻制种高产栽培技术. 四川科技出版社

Tian D (1991) 水稻异交栽培学. 四川科技出版社

专著

田大成 (1991) 水稻异交栽培学. 四川科技出版社

获奖情况

1. 1993年：国家科技进步三等奖

（杂交水稻制种高产稳产新技术研究，第一主持人）

2. 1991年：四川省科技进步一等奖

（杂交水稻制种高产稳产新技术研究，第一主持人）

专利